{"id":14828,"date":"2008-11-14T04:47:03","date_gmt":"2008-11-14T04:47:03","guid":{"rendered":"https:\/\/dev.jinekomasti.com\/2008\/11\/14\/kardiyovaskueler-laclar-ve-dermatolojik-yan-etkileri\/"},"modified":"2008-11-14T04:47:03","modified_gmt":"2008-11-14T04:47:03","slug":"kardiyovaskueler-laclar-ve-dermatolojik-yan-etkileri","status":"publish","type":"post","link":"https:\/\/jinekomasti.com\/en\/jinekomasti-makaleleri\/tibbi-makaleler\/kardiyovaskueler-laclar-ve-dermatolojik-yan-etkileri\/","title":{"rendered":"Kardiyovask\u00fcler \u0130la\u00e7lar ve Dermatolojik Yan Etkileri"},"content":{"rendered":"

Amlodipin<\/strong>: Deri reaksiyonlar\u0131n\u0131n g\u00f6r\u00fclme oran\u0131 % 1 den azd\u0131r. Bunlar pruritus, eritemat\u00f6z d\u00f6k\u00fcnt\u00fc, makulopap\u00fcler d\u00f6k\u00fcnt\u00fc, purpura, jinjival hiperplazi ve jinekomastidir<\/span>. Nontrombositopenik purpura, eritema multiforme de olu\u015fabilmektedir.51,52<\/p>\n

Verapamil:<\/strong> Y\u00fczde k\u0131zarma, pruritus, jinjival hiperplazi, jinekomasti<\/span>, hiperkeratoz, makulopap\u00fcler d\u00f6k\u00fcnt\u00fcler, terleme, ekimoz ve alopesiye neden olmaktad\u0131r. Hipertrikozis de (tedaviden 3-4 hafta sonra kel olan bir hastada sa\u00e7 \u00e7\u0131kmas\u0131..) rapor edilmi\u015ftir. Ekimozlar, purpurik vask\u00fclit lezyonlar\u0131, \u00fcrtiker, eritema multiforme ve Stevens-Johnson sendromu (% 1 den az) olu\u015fmaktad\u0131r. Deri reaksiyonlar\u0131 daha \u00e7ok egzamal\u0131 kad\u0131nlar\u0131n % 72 sinde g\u00f6r\u00fclmektedir. Oral verapamil kullanan hastalar\u0131n % 1 inden az\u0131nda eritema multiforme veya Stevens-Johnson sendromu g\u00f6r\u00fcl\u00fcr.56<\/sup><\/p>\n

<\/p>\n

Dijital glikozidleri<\/strong>: Deri reaksiyonlar\u0131 seyrektir ve jinekomasti<\/span>, \u00fcrtiker, kabuklanma, alopesi, parmak ucu ve t\u0131rnaklarda \u00e7atlaklar ve makulopap\u00fcler d\u00f6k\u00fcnt\u00fc di\u011fer etkileridir.59<\/p>\n

Spironolacton:<\/strong> Yan etkisi \u00e7ok az bir potasyum tutucu di\u00fcretiktir. Dermal yan etkileri ilac\u0131n di\u011fer yan etkilerinin % 2.4 \u00fcd\u00fcr. Bunlar likenoid reaksiyonlar, makulopap\u00fcler egzama, \u00fcrtiker, trombositopenik purpura, hirsutizm ve egzema lezyonlar\u0131d\u0131r. Gynecomastia<\/span> ve memelerde hassasiyet bildirilmektedir.76<\/p>\n

Methyldopa:<\/strong> Dermal reaksiyonlar\u0131 seyrektir. Daha \u00e7ok birlikte kullan\u0131lan ila\u00e7lar reaksiyonludur. Eritema multiforme, trombositopenik purpura, generalize pruritus ve alt ekstremite \u00fclserasyonlar\u0131, dilde paslanma ve jinekomasti<\/span>, ilaca ba\u011fl\u0131 lupus, hipersensitivite g\u00f6r\u00fclebilir. 2 y\u0131l s\u00fcreyle metildopa kullanan 74 ya\u015f\u0131ndaki bir erkek hastada yayg\u0131n eritemat\u00f6z d\u00f6k\u00fcnt\u00fc, ate\u015f, lenfadenopati geli\u015fti\u011fi ila\u00e7 kesildikten sonra bulgular\u0131n tamamen kayboldu\u011fu bildirilmektedir.82,83<\/p>\n

Clofibrat:<\/strong> Seyrek olarak d\u00f6k\u00fcnt\u00fc, jinekomasti<\/span>, deride kuruma ve sa\u00e7ta k\u0131r\u0131lma, alopesi ve pruritus g\u00f6r\u00fcl\u00fcr. Eritema multiforme, Stevens-Johnson sendromu, toksik epidermal nekroliz ve lupus benzeri sendrom rapor edilmi\u015ftir.99<\/p>\n

51.<\/strong> Seymour RA, Ellis JS, Thomason JM. Amlodipin-induced gingival over growth. J Clin Periodontol 1994: 21; 281-283.
52.<\/strong> Dacosta A, Mismetti P, Tardy B. Non-thrombopenic purpura induced by amlodipine. Therapie 1994; 49: 515-517.
56<\/strong>. K\u00fcrk\u00e7\u00fco\u011flu N, Alaybeyi F. Erythema multiforme after verapamil treatment. J Am Acad Dermatol 1991; 24: 511-512
59<\/strong>. David M, Livni E, Stern E, Feuerman EJ, Grinblatt J. Psoriasiform eruption induced by digoxin: confirmed by re-exposure. J Am Acad Dermatol 1981; 5: 702-703.
76.<\/strong> Danby FW. Spironolactone. J Am Acad Dermatol 1992; 26: 137.
82.<\/strong> Vaillant L, Le Maarchand D, Grognard C, Hocine R, Lorette G. Photosensitivity to methyldopa. Arch Dermatol 1988: 124; 326-327.
83.<\/strong> Wells JD, Kurtay M, Lochner JC. Granulomatouus skin lesions and alpha-methyl dopa. Ann Intern Med 1974: 81; 701-702.
99.<\/strong> Wong SS. Stevens-Johnson syndrome induced by clofibrate. Acta Derm Venereol 1994; 74: 475.<\/p>","protected":false},"excerpt":{"rendered":"

Amlodipin: Deri reaksiyonlar\u0131n\u0131n g\u00f6r\u00fclme oran\u0131 % 1 den azd\u0131r. Bunlar pruritus, eritemat\u00f6z d\u00f6k\u00fcnt\u00fc, makulopap\u00fcler d\u00f6k\u00fcnt\u00fc, purpura, jinjival hiperplazi ve jinekomastidir. Nontrombositopenik purpura, eritema multiforme de olu\u015fabilmektedir.51,52 Verapamil: Y\u00fczde k\u0131zarma, pruritus, jinjival hiperplazi, jinekomasti, hiperkeratoz, makulopap\u00fcler d\u00f6k\u00fcnt\u00fcler, terleme, ekimoz ve alopesiye neden olmaktad\u0131r. Hipertrikozis de (tedaviden 3-4 hafta sonra kel olan bir hastada sa\u00e7 \u00e7\u0131kmas\u0131..) rapor […]<\/p>\n","protected":false},"author":31244,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[311],"tags":[],"class_list":["post-14828","post","type-post","status-publish","format-standard","hentry","category-tibbi-makaleler"],"blocksy_meta":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/posts\/14828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/users\/31244"}],"replies":[{"embeddable":true,"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/comments?post=14828"}],"version-history":[{"count":0,"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/posts\/14828\/revisions"}],"wp:attachment":[{"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/media?parent=14828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/categories?post=14828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jinekomasti.com\/en\/wp-json\/wp\/v2\/tags?post=14828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}